Introduction

Introduction

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There have been several technological developments since DNA testing was introduced into forensic science laboratories in the United States during the late 1980s. The historical developments are described in Subject 01 Module 02. The current technology is short tandem repeat (STR)analysis using the polymerase chain reaction (PCR).

The Human Genome Project has shown that there are tens of thousands of STR loci in human DNA. The selection of specific loci from the many available for use in forensic science laboratories is important for many reasons, but primarily to ensure that:

The loci have a high discriminating power.
The loci are stable in evidence samples.
There is a consensus panel of core loci for use in DNA databases.

Objectives

Upon successful completion of this unit of instruction, the student shall be able to:

Describe the established core STR loci used in the United States.
Describe how loci are selected for use in forensic STR analysis in the United States.
List STR kit manufacturers.
Describe the established core Y-STR loci in the United States.

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