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Mixtures with Known Contributor(s)

Home > STR Data Analysis & Interpretation > Data Interpretation and Allele Calls > Mixtures > Mixtures with Known Contributor(s)

It is common to obtain samples where one of the contributors (e.g., the victim) is known. In these cases, it may be possible to infer an unknown profile by subtracting the contribution of the known donor from the mixed profile.01 

In general, this approach is taken on intimate samples such as vaginal swabs, fingernails, breast swabs, neck swabs, and clothing items removed from a person’s body in situations where it is likely that there are no more than two contributors. It may be possible to infer unknown profiles from mixtures with more than two contributors, but is considerably more complex.

An analyst can use percent mixture contribution and peak height percentages to aid in inferring profiles from mixtures with known contributors.

Click here to view an animation about how a known contributor sample can be used to infer the profile of an unknown contributor to a mixture.

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